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Analysis of Ampoule Washing Drying Filling Sealing Production Line

2023-07-20

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Marya

This article analyzes and summarizes the operating procedures and production equipment characteristics of ampoule washing drying filling sealing production line, and describes in detail the application of industrial automation in this linkage production line. The original intention is to promote the further application of ampoule washing drying filling sealing production line in pharmaceutical production.

Abstract: This article analyzes and summarizes the operating procedures and production equipment characteristics of ampoule washing drying filling sealing production line, and describes in detail the application of industrial automation in this linkage production line. The original intention is to promote the further application of ampoule washing drying filling sealing production line in pharmaceutical production.


The application and implementation of industrial automation technology in pharmaceutical equipment products means further optimization of the drug production process for users of pharmaceutical production factories. As an equipment engineer engaged in industrial automation in the pharmaceutical industry, the engineer is not only necessary to be familiar with pharmaceutical production processes and equipment, but also to have experience in measurement, analysis, design, and application in the field of automation technology in order to solve various practical problems with ease. The following text elaborates on the application of industrial automation technology through an example of ampoule washing drying filling sealing production line, with the aim of further promoting its application in pharmaceutical production.

1、Brief Introduction to ampoule washing drying filling sealing production line


The ampoule washing drying filling sealing production line is a small capacity injection production line that combines the three processes of ampoule bottle washing, drying, sterilization, and medicine filling and sealing. It achieves synchronous and coordinated operation of injection production, which not only saves investment in workshops and factory and premises, but also reduces intermediate turnover of semi-finished products, minimizing the possibility of drug contamination. The ampoule washing drying filling sealing production line adopts advanced technologies such as ultrasonic cleaning, multi needle alternating water and gas flushing, hot air laminar flow disinfection and sterilization, laminar flow purification, multi needle filling and sealing, and wire drawing sealing. The entire machine adopts serial ampoule bottles for feeding and discharging, avoiding cross contamination. The entire production process operates under sealed or laminar flow conditions.
At the same time, advanced automation system integration technology has been adopted to achieve the integration of mechanical and electrical instruments, enabling the entire production process to achieve automatic balance, monitoring and protection, automatic temperature control, automatic recording, automatic alarm, and fault display, reducing labor intensity and operators. Referring to the process flow of washing, drying, filling, and sealing for final sterilization small capacity injections, the production line will be installed in areas spanning two different cleanliness levels. The bottle washing and sterilization tunnel will be located in a 100000 level clean area, and the filling and sealing will be located in a 10000 level clean area. The operators are divided into two groups, one group operating the bottle washing equipment and sterilization tunnel equipment and the other group operating the filling and sealing equipment.

 

2、Operating procedures for ampoule washing drying filling sealing production line


Most of the bottle washing equipment is used for cleaning ampoule bottles. This advanced equipment can automatically complete the process of cleaning from the bottle feeding, ultrasonic cleaning, external and internal washing of ampoule bottles, and finally the bottle discharge.

The process of the ampoule washing equipment is as follows: the ampoule first slides down from the bottle feeding hopper, stays in a constant temperature water tank for thorough ultrasonic washing, and then the ampoule is immersed in water by the bottle feeding screw, which separates and transports the ampoule bottle to the lifting pulley. The ampoule is then grabbed by a mechanical arm, flipped 180 degrees, and the bottle mouth is kept downward, spraying the inside and outside of the ampoule repeatedly with circulating water at a temperature of approximately 80 degrees Celsius. Then, compress the air to spray the inside of the ampoule, and then compress the air to spray the inside and outside of the ampoule. After spraying, wash the inside of the ampoule with injection water. After washing, proceed to the previous level of spraying, that is, compress the air to spray the inside of the ampoule , and spray the inside and outside of the ampoule. After spraying, the robotic arm holding the ampoule flips 180 degrees to make the bottle mouth face upwards. The ampoule is then transported to the outlet thumbwheel and finally to the tunnel for sterilization in the next process. The above is a detailed description and summary of the operation process of the ampoule washing equipment.

According to the process of the ampoule washing drying filling sealing production line, the ampoule enters the equipment entrance of the sterilization tunnel, where heat is transferred and convection equipment is used to maintain the continuity of sterilization and heat source removal for the ampoule bottle.The ampoule enters the non sterile port of the tunnel, transported inside the tunnel, surrounded by various temperatures of air, cooled by high-efficiency filters, and then transported to the next filling and sealing.

The ampoule is transported to the lead-in equipment, through the bottle feeding screw and the bottle feeding thumbwheel, into the filling station, and then pre-filled with protective gas for medicine filling, and then filled with protective gas for the preheating procedure before sealing, and then through the wire drawing and sealing stage of the ampoule. The final cleaning of the ampoule finished product after high-temperature sterilization is completed and transported to the outlet of the machine.

3、Application of industrial automation system in ampoule washing drying filling sealing production line


Compared with previous similar production lines, this production line adopts more advanced electrical control groups and control technologies, which is more convenient for on-site application and debugging. The signal is transmitted on the fieldbus and Ethernet, eliminating the need to lay a large number of cable lines as before, reducing the number of fault points and saving costs.

 


4、Conclusion


After a brief and powerful overview of ampoule washing drying filling sealing production line, this article analyzes and summarizes its operating procedures, industrial automation system integration solutions, and applications. It is concluded that this linkage production line has the advantages of reducing production costs for enterprises and promoting technological innovation, which is conducive to the further application of pharmaceutical production.