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How to choose a small batch filling solution

2023-08-16

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Marya

With the vigorous development of the pharmaceutical industry, the demand for flexible and efficient small batch filling by domestic and foreign pharmaceutical companies is constantly increasing. How to choose reliable small batch partners and how to choose specific solutions have become topics of concern for many people. After reading this article, you will definitely gain something.

With the vigorous development of the pharmaceutical industry, the demand for flexible and efficient small batch filling by domestic and foreign pharmaceutical companies is constantly increasing. How to choose reliable small batch partners and how to choose specific solutions have become topics of concern for many people. After reading this article, you will definitely gain something.

 

1. How to choose reliable small batch partners

 

Many times there is no absolute right or wrong choice, but how to make a truly suitable choice for oneself is a university question. At present, it is not uncommon for companies to hype up small batches as a concept, but looking at the entire pharmaceutical industry, there are only a few companies that are at the forefront of technology and have accumulated rich practical experience in this field. Whether you are an innovative company or a mature medium to large enterprise with a certain scale, it is recommended that you have a thorough understanding and objective comparison of the topic before choosing. Whether it is for risk control or long-term benefits, collaborating with suppliers with leading technology and rich practical experience in small batch filling is a wise choice.

 

2. How to choose a specific solution

 

As mentioned earlier, there are currently few companies with advanced technology and rich experience in small batch filling, and even fewer can provide comprehensive solutions. In the past three years, Marya has relied on its high-quality reputation to turn small batch filling products into popular products, selling well in multiple countries and regions around the world. It also has various small batch filling solutions available for everyone to choose from: vial filling capping machine, prefilled syringe filling machine, cartridge filling sealing machine.

 

（1）Vial Filling Capping Machine

 

If you want to handle RTU vial bottles in the form of pallets, you can choose vial filling capping machine for small batch product filling. By manually opening the bag, feeding with a rotary table, and subsequently connecting with the filling and capping machine for filling and capping, the production capacity can reach 60-100 bottles per minute (based on the number of filling needles). Customers can choose customized functions according to their own needs, such as servo control/piston pump/time pressure filling system/peristaltic pump/nitrogen filling/rabs/isolator. The above solution can not only handle RTU packaging materials, but also be applied to commercial production in the future.

  

 

（2）Prefilled Syringe Filling Machine

 

Designed specifically for high-speed and ultra high-speed processing of pre-sterilized honeycomb syringes. The transmission carrier moves independently through a servo drive device. Pharmaceutical grade processing units are used for filling needle movement and provide extremely precise filling, needle accuracy, and adaptability for different specifications and products. The production capacity can reach 70-100 bottles per minute (based on the number of filling needles). Customers can choose customized functions according to their own needs, such as ceramic rotary valve pumps/open RABS/closed RABS/closed systems/isolation systems.

 

 

（3）Cartridge Filling Sealing Machine

 

Nest box RTU cartridge bottles are brought to the filling machine in the clean room in single or double bag form and unpacked in half or full process. There are two main methods for transferring nest boxes to sterile areas (electron beam or external purification using H2O2, NTT). Marya filling sealing machine can perform automatic bag removal, automatic removal of tyvec, automatic removal of sealing paper, as well as vacuum filling and stoppage operations, which can prevent any microbial contamination.

  

 

As more and more biopharmaceuticals are introduced to the market, the challenges of processing these products and their filling processes are also increasing. Therefore, choosing reliable and experienced partners and suitable solutions is particularly important, which helps to successfully address these challenges. Marya not only has mature technology in small batch filling, but also has over 20 years of experience in one-stop service for isolators - from filling equipment to isolators themselves; From biological purification and air treatment technology to the confirmation and validation of the entire system.